Sinusitis FAQ

Sinusitis May Have A Genetic Component

Question:

Genes Linked to Sinusitis The discovery could lead to new treatments for the respiratory condition that affects some 37 million Americans, researchers say. By Steven Reinberg HealthDay Reporter FRIDAY, Oct. 8 (HealthDayNews) — A new study contends sinusitis seems to have genetic underpinnings, and the finding might one day lead to new treatments for the condition that clogs the nasal passages of some 37 million Americans each year. After a three-year analysis, Johns Hopkins scientists came to the conclusion that sinus disease may be caused by genes that produce too much or too little of certain proteins; one gene shows particular promise as a possible treatment. The report appears in the Oct. 8 online issue of the Journal of Allergy and Clinical Immunology…. The new findings give clues to which genes may play a role in controlling this illness, the researchers said…. Kim’s team found that, when compared with healthy tissue, 192 genes were up-regulated in diseased tissue and 156 were down-regulated. Why certain genes do that in sinus disease is not known, Kim said. "The most interesting finding was that the most down-regulated gene was the protein CC10," Kim said. "This protein is present in respiratory tissues and is necessary for neonatal lung development." In addition, CC10 is being used now to help neonatal lung development in premature babies, Kim noted. "Perhaps if we were to replace the level of CC10, we could have a good treatment for sinus disease," she said. Replacing the levels of CC10 in diseased tissue is the next step in the team’s research, Kim added…. http://drkoop.com/newsdetail/93/521657.html [ IMHO, this finding is consistent with the Mayo Clinic's own theory of allergic fungal sinusitis.  Mayo couldn't explain why some patients' sinuses react to the presence of fungi and other folks don't react that way.  Perhaps the difference is genetic. ] — Steven D. Litvintchouk Email:  sdlit…@earthlinkNOSPAM.net Remove the NOSPAM before replying to me.

Response:

Scooped you on that back on 10/8.  I was surprised no one reacted to it. http://groups.google.com/groups?hl=en&lr=&c2coff=1&safe=off&threadm=4… or http://tinyurl.com/4cmpj – Hide quoted text — Show quoted text -Steven Litvintchouk wrote: > Genes Linked to Sinusitis > The discovery could lead to new treatments for the respiratory condition > that affects some 37 million Americans, researchers say. > By Steven Reinberg > HealthDay Reporter > FRIDAY, Oct. 8 (HealthDayNews) — A new study contends sinusitis seems > to have genetic underpinnings, and the finding might one day lead to new > treatments for the condition that clogs the nasal passages of some 37 > million Americans each year. > After a three-year analysis, Johns Hopkins scientists came to the > conclusion that sinus disease may be caused by genes that produce too > much or too little of certain proteins; one gene shows particular > promise as a possible treatment. > The report appears in the Oct. 8 online issue of the Journal of Allergy > and Clinical Immunology…. > The new findings give clues to which genes may play a role in > controlling this illness, the researchers said…. > Kim’s team found that, when compared with healthy tissue, 192 genes were > up-regulated in diseased tissue and 156 were down-regulated. Why certain > genes do that in sinus disease is not known, Kim said. > "The most interesting finding was that the most down-regulated gene was > the protein CC10," Kim said. "This protein is present in respiratory > tissues and is necessary for neonatal lung development." > In addition, CC10 is being used now to help neonatal lung development in > premature babies, Kim noted. "Perhaps if we were to replace the level of > CC10, we could have a good treatment for sinus disease," she said. > Replacing the levels of CC10 in diseased tissue is the next step in the > team’s research, Kim added…. > http://drkoop.com/newsdetail/93/521657.html > [ > IMHO, this finding is consistent with the Mayo Clinic's own theory of > allergic fungal sinusitis.  Mayo couldn't explain why some patients' > sinuses react to the presence of fungi and other folks don't react that > way.  Perhaps the difference is genetic. > ]

Response:

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