Sinusitis FAQ

Raynaud's Phenomenon

Question:

Interesting!  I have been diagnosed with Reynaud’s for about 5 years now.  Had no idea it was related to also being diabetic!

Response:

Interesting!  I have been diagnosed with Reynaud’s for about 5 years now.  Had no idea it was related to also being diabetic!

I have been studying the effects of hemodilution due to the fact it seems to be ‘glorified’ .. bloodletting. I ran across this study for Raynaud’s .. It seems the ‘word’ hemodilution is used in various .. contexts. One context is .. extreme blood loss = hemodilution .. which to me would mean .. bloodletting .. ?    Major blood loss, however,results in extreme    hemodilution, and the transfusion of red blood cells may finally    become necessary to maintain      arterial oxygen content and to preserve tissue oxygenation. It seems it greatly improves circulation .. due to the ‘thinning’ of the blood.    V.A. Mamurov    Therapeutic effect of prolonged normovolemic hemodilution in patients    with Raynaud’s disease    51 patients with Raynaud’s disease hase undergone prolonged    normovolemic hemodilution (PNH) with a good effect. Disappearance of    painful syndrome in 78,43% of cases, and a significant decrease of    pains in 21,37% of cases was demonstrated. Complete healing of    ulcero-necrotic defects of end phalanges of the hands was observed in    7 patients of 10 and partial – in 3. A significant remission of the    disease in follow-up period was obtained. Thus, prolonged normovolemic    hemodilution has resulted in significant improvement of short- and    long-term results of treatment in patients with Raynaud’s disease. These aricles speak to the effects of hemodilution. It seems even ‘extreme’ anemia does not affect the oxygen in the blood at all.. ?    Vestn Khir Im I I Grek 1991 Jun;146(6):33-6 [Blood rheological disorders in patients with postthrombotic disease and the means for their correction].    [Article in Russian]     Kargin VD, Khlebnikov VA, Fregatova LM    An analysis of results of rheological properties of blood in 45    patients with different forms of postthrombotic disease of lower    extremities has shown that 78% of the patients have erythrocytosis and    all the patients have hyperviscosity shifts. Correction of the    hemorheological changes by the methods of transfusion therapy    (plasmapheresis, exfusion of blood, hemodilution) allowed to reduce    the microcirculatory disorders in the diseased extremity in this group    of patients.    PMID: 1668489, UI: 92377110    Save the above report in [Macintosh] [Text] format    Order documents on this page through Loansome Doc    Int Angiol 1986 Jul-Sep;5(3):151-4 Isovolemic hemodilution: a therapeutical intervention for improving microcirculation.     Rudofsky G    A controlled reduction of hematocrit levels can be of value in the    conservative treatment of inoperable arterial occlusive disease in    advanced clinical stages. Long term success can be achieved in up to    nearly 50%. The more and the longer the occlusions, the poorer the    results.    PMID: 3559316, UI: 87167905    Save the above report in [Macintosh] [Text] format    Order documents on this page through Loansome Doc    Angiology 1986 Feb;37(2):124-7 Peripheral vascular disease: flow studies and clinical results after isovolemic hemodilution–case reports.     Caputi CA, De Carolis G    The authors, after a brief introduction concerning hemorheology    pathophysiology, report the results of a study on 18 patients    suffering from vascular disease at the second, third and fourth stage    (Fontaine) who underwent isovolemic hemodilution therapy. The Travis    Winsor index (evaluated by Doppler ultrasound) and the perfusion    volume (evaluated by impedance rheography) were both significantly    increased after treatment. In some patients such increase were also    associated with a reduction of subjective symptoms.    PMID: 3954151, UI: 86156986    Save the above report in [Macintosh] [Text] format    Order documents on this page through Loansome Doc    Acta Med Austriaca 1991;18 Suppl 1:23-7 [Hyper- or isovolemic hemodilution in patients with stage II peripheral arterial occlusive disease].    [Article in German]     Kiesewetter H, Jung F, Blume J, Spitzer S, Birk A    Abteilung fur Klinische Hamostaseologie und Transfusionsmedizin,    Universitat des Saarlandes, Homburg Saar, BRD.    The influence of hyper- and isovolaemic hemodilution using HES 200/0.5    6% (HES steril, Fresenius AG) on pain-free walking distance in    patients with peripheral arterial occlusive disease stage II according    to Fontaine was tested in a randomised investigation involving three    groups. The increase in pain-free walking distance was significant    both in the hypervolaemic and isovolaemic hemodilution group. The    increase in both dilution groups did not differ but compared to a    control group (infusion of Ringer lactate) it was significantly    higher. Considerable changes concerning rheological parameters    (decrease in haematocrit and plasma viscosity) were observed after    isovolaemic hemodilution.    Publication Types:      * Clinical trial      * Randomized controlled trial    PMID: 1719729, UI: 92057498    Save the above report in [Macintosh] [Text] format    Order documents on this page through Loansome Doc    Vestn Khir Im I I Grek 1987 Sep;139(9):19-24 [Dynamics of regional blood circulation in normovolemic hemodilution in patients with arterial occlusive diseases].    [Article in Russian]     Kuznetsov NA, Bogdanov AE    Normovolemic hemodilution was used in 81 patients as preparation to    reconstructive operation for the occlusion of main arteries of    extremities. Regional hemodynamics was studied in 18 of them. It was    established that acute hemodilution substantially increased the volume    and tissue blood flow, regional systolic arterial pressure distal to    the occlusion of the main vessel and reestablished the vessel tone.    The oxygen transport became normal in the zones with preserved main    blood flow and considerably increased in the places distal to the    occlusion of the main artery.    PMID: 3441964, UI: 88159982    Save the above report in [Macintosh] [Text] format    Order documents on this page through Loansome Doc    HYPEROXIA IN EXTREME HEMODILUTION    O. Habler    , K. Me

Filed under: Pathophysiology

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