Sinusitis FAQ

paging Teri Roberts

Question:

- Hide quoted text — Show quoted text – MM has been THE leading migraine researcher for about the last 25 years. After I answered "boxingnut", I went to the link he provided only to "boxingnut" asked for. Apparently, he doesn’t read what he posts. Also, one needs to have a background in medicine in order to understand MM’s writings. MM, with the help of others,  provided the theoretical basis for sumatriptan, btw. That’s his contribution. Only took a couple of decades. Hi, Richard. As Jack said, Dr. Moskowitz is a pioneer researcher and theorist. Looking at the URL you posted, it looks as if some of his current work could also lead to more effective preventives. There are links on that page to abstracts of his publications. You might find them interesting reading. I know I’ll be marking that page so I can go back and read them. Teri This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Thanks Jack. I tried going through the articles attributed with MM but I couldn’t really decipher them to my satisfaction.  I was hoping someone might have more info in layman’s terms I could access.  Sounds like he’s on the right track. My wife can’t tolerate the triptans. She gets very unbearable chest pain and has even broken into hives. I’m hoping a new class of medication, which is more specific, will soon be available. Richard The Hubby

Response:

MM has been THE leading migraine researcher for about the last 25 years. After I answered "boxingnut", I went to the link he provided only to "boxingnut" asked for. Apparently, he doesn’t read what he posts. Also, one needs to have a background in medicine in order to understand MM’s writings. MM, with the help of others,  provided the theoretical basis for sumatriptan, btw. That’s his contribution. Only took a couple of decades. – Hide quoted text — Show quoted text – Hi, Richard. As Jack said, Dr. Moskowitz is a pioneer researcher and theorist. Looking at the URL you posted, it looks as if some of his current work could also lead to more effective preventives. There are links on that page to abstracts of his publications. You might find them interesting reading. I know I’ll be marking that page so I can go back and read them. Teri This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

Hi, Richard. As Jack said, Dr. Moskowitz is a pioneer researcher and theorist. Looking at the URL you posted, it looks as if some of his current work could also lead to more effective preventives. There are links on that page to abstracts of his publications. You might find them interesting reading. I know I’ll be marking that page so I can go back and read them. Teri

– Hide quoted text — Show quoted text – This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

If you’re talking about Michael Moskowitz at Harvard neurolgy, he’s one of the leading theorist in migraine research, and the trigemino-vascular theory (current theory) is attributable to him. Jack – Hide quoted text — Show quoted text – This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

Have you tried any of the ergotamines such as DHE 45 or the Migranal for your wife? Michelle

– Hide quoted text — Show quoted text – MM has been THE leading migraine researcher for about the last 25 years. After I answered "boxingnut", I went to the link he provided only to "boxingnut" asked for. Apparently, he doesn’t read what he posts. Also, one needs to have a background in medicine in order to understand MM’s writings. MM, with the help of others,  provided the theoretical basis for sumatriptan, btw. That’s his contribution. Only took a couple of decades. Hi, Richard. As Jack said, Dr. Moskowitz is a pioneer researcher and theorist. Looking at the URL you posted, it looks as if some of his current work could also lead to more effective preventives. There are links on that page to abstracts of his publications. You might find them interesting reading. I know I’ll be marking that page so I can go back and read them. Teri This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby Thanks Jack. I tried going through the articles attributed with MM but I couldn’t really decipher them to my satisfaction.  I was hoping someone might have more info in layman’s terms I could access.  Sounds like he’s on the right track. My wife can’t tolerate the triptans. She gets very unbearable chest pain and has even broken into hives. I’m hoping a new class of medication, which is more specific, will soon be available. Richard The Hubby

Response:

1) Delayed inflammation in rat meninges: implications for migraine pathophysiology – Nitric oxide in humans (in the blood stream) has been found to cause migraines 4 to 6 hours after being administered. By introducing an enzyme to stop the formation of nitric oxide from that drug, two thirds of migraineurs had less painful headaches as a result. In a rat treated as though it were a human (which is pretty standard for drug development and pretty good as an indicator) levels of nitric oxide were induced in the brain. Then they watched what chemicals, etc. were secreted in the rat and where they occurred in order to find out what was doing the reaction. The conclusion was that it was the "dura mater", a layer of cells surrounding the brain, and not the brain itself, that was reacting to the presence of nitric oxide. They noticed this between 2 and 6 hours after administering the drug. The hypothesis is that the same effect happens in humans. This gives them 2 targets – to stop nitric oxide formation and to alleviate the reaction within the dura mater; also if the time delay allows treatment or not (once it’s started you may have to treat the symptoms and not the cause). – Hide quoted text — Show quoted text – This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

I believe much such information is in the Google archives. It’s very complicated, and requires a background for this material. Anyone REALLY interested could search Medline and Google. From Medline, one can order the original articles. They are also linked to by his site below. I don’t think I could write a laymans’s version of curent migraine theory. I’ve thought about it many times, but it requires I assume too much on the part of the reader to not compromise science without writing a basic science text——,no thank you.  Those who are motivated can find it. After all, I’m not suggesting anyone drive to the library, park, walk, and hunt throught the stacks, before heading for the change machine to use the copier. Nothing that radical. Jack – Hide quoted text — Show quoted text – Maybe so. I have only just started looking into this and settled for a quickie translation of the published piece. What would be good is if you could contribute to the other thread on "Research into migraine" with a summary of his theories and the papers that have been published to follow it up. How about it? Then we can all benefit – I am only an "informed layman", after all, and not a doctor or pharmacologist. Moskowitz’s work came long before the nitric oxide ideas. Moskowitz’s theory, IMHO, is nowhere to be found in the text below: Jack 1) Delayed inflammation in rat meninges: implications for migraine pathophysiology – Nitric oxide in humans (in the blood stream) has been found to cause migraines 4 to 6 hours after being administered. By introducing an enzyme to stop the formation of nitric oxide from that drug, two thirds of migraineurs had less painful headaches as a result. In a rat treated as though it were a human (which is pretty standard for drug development and pretty good as an indicator) levels of nitric oxide were induced in the brain. Then they watched what chemicals, etc. were secreted in the rat and where they occurred in order to find out what was doing the reaction. The conclusion was that it was the "dura mater", a layer of cells surrounding the brain, and not the brain itself, that was reacting to the presence of nitric oxide. They noticed this between 2 and 6 hours after administering the drug. The hypothesis is that the same effect happens in humans. This gives them 2 targets – to stop nitric oxide formation and to alleviate the reaction within the dura mater; also if the time delay allows treatment or not (once it’s started you may have to treat the symptoms and not the cause). This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

Moskowitz’s work came long before the nitric oxide ideas. Moskowitz’s theory, IMHO, is nowhere to be found in the text below: Jack – Hide quoted text — Show quoted text – 1) Delayed inflammation in rat meninges: implications for migraine pathophysiology – Nitric oxide in humans (in the blood stream) has been found to cause migraines 4 to 6 hours after being administered. By introducing an enzyme to stop the formation of nitric oxide from that drug, two thirds of migraineurs had less painful headaches as a result. In a rat treated as though it were a human (which is pretty standard for drug development and pretty good as an indicator) levels of nitric oxide were induced in the brain. Then they watched what chemicals, etc. were secreted in the rat and where they occurred in order to find out what was doing the reaction. The conclusion was that it was the "dura mater", a layer of cells surrounding the brain, and not the brain itself, that was reacting to the presence of nitric oxide. They noticed this between 2 and 6 hours after administering the drug. The hypothesis is that the same effect happens in humans. This gives them 2 targets – to stop nitric oxide formation and to alleviate the reaction within the dura mater; also if the time delay allows treatment or not (once it’s started you may have to treat the symptoms and not the cause). This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

Maybe so. I have only just started looking into this and settled for a quickie translation of the published piece. What would be good is if you could contribute to the other thread on "Research into migraine" with a summary of his theories and the papers that have been published to follow it up. How about it? Then we can all benefit – I am only an "informed layman", after all, and not a doctor or pharmacologist. – Hide quoted text — Show quoted text – Moskowitz’s work came long before the nitric oxide ideas. Moskowitz’s theory, IMHO, is nowhere to be found in the text below: Jack 1) Delayed inflammation in rat meninges: implications for migraine pathophysiology – Nitric oxide in humans (in the blood stream) has been found to cause migraines 4 to 6 hours after being administered. By introducing an enzyme to stop the formation of nitric oxide from that drug, two thirds of migraineurs had less painful headaches as a result. In a rat treated as though it were a human (which is pretty standard for drug development and pretty good as an indicator) levels of nitric oxide were induced in the brain. Then they watched what chemicals, etc. were secreted in the rat and where they occurred in order to find out what was doing the reaction. The conclusion was that it was the "dura mater", a layer of cells surrounding the brain, and not the brain itself, that was reacting to the presence of nitric oxide. They noticed this between 2 and 6 hours after administering the drug. The hypothesis is that the same effect happens in humans. This gives them 2 targets – to stop nitric oxide formation and to alleviate the reaction within the dura mater; also if the time delay allows treatment or not (once it’s started you may have to treat the symptoms and not the cause). This is for Teri or anyone else who might know more about this Doctors’ research. His name is Moskowitz and here is a website I’ve had for some time on him. I can’t find anything else and I’d like to know if anyone else does.  He seems to be working on a more precise targeting of the origin point of the migraine process and looking to develop more specific classes of drugs to abort the process. http://research.neurosurgery.mgh.harvard.edu/moskowitz.htm Thanks Richard the Hubby

Response:

Filed under: Pathophysiology

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