Sinusitis FAQ

~ Food Induced Cushings ~

Question:

Are you getting enough Chromium Picolinate 200 mcg? This is supposed to relieve glucose intolerance. A deficiency of Chromium Picolinate can result in Adult Onset Diabetes. One other note, don’t eat Froot Loops Cereal in front of the TV set! Check out The Vitamin Shoppe online at www.vitaminshoppe.com or call 1-800-223-1216 and have them send you a catalog of all the fine products they have on sale for mail-order. I’d tell you to get other pills that they sell which would be beyond the scope of all medical practice but why don’t you get back to me here after you spend a few weeks taking Chromium Picolinate.

Response:

Hi Gang – PLEASE REPOST I’m posting this information to help with other peoples quest to try and pin down their symptoms.  Please repost this to as many news groups and Cushings websites you may know of as it valuable information about a rare form of Cushings. Many of the symptoms of Cushings relate to many problems both physically and mentally. http://www.cushingssyndrome.org/search.asp Don’t let some of the medical terms be a detour to researching the symptoms online.  Many many people go undiagnosed for years. GOOD NEWS I accidentally came across a mention of "Food Induced Cushings" researching articles about the "Salivary Cortisol Test".  Meanwhile it can be found at: http://pituitarysociety.med.nyu.edu/raff.htm Cushings causes Cortisol (the flight or fight hormone) to be over produced.  And when constantly released into the body can be very damaging and can cause different reactions depending on the person. I contacted Dr. Raff and explaining how I have been diagnosed with Cushings Disease with my high ACTH, Cortisol, and an MRI showing the benign tumor on my pituitary gland (in the brain).  But the normal Cushings symptoms weren’t always consistent with the typical Cushings Disease because it occured whenever I ate food. The symptoms I experienced was immediately upon eating food.  They are "brain fog", mood swing, lost, disorientation, confusion, body aches, skin sensitivity, depression, and sudden exhaution. The feeling is as if you have pulled two all nighters studying. This can last for 15 minutes to all day. I react very violently to high-glycemic foods and caffeine which I avoid. It has gradually gotten worse over the past year and I react now to all foods. It’s inconsistent though as to what foods will trigger the level of reaction. I thought I was allergic to sugar (glucose intolerant) or have hyperthyroidism (Graves disease) as it runs in my family.  I was tested for these and many other things with none of them being positive. It turns out that my symptoms to not correlate to Food Induced Cushings because of having elevated ACTH levels.  But this is such rare information that I wanted to post it to have record of it. (Incidentally he suggested that I may have developed early Type 2 Diabetes Mellitus but I have monitored my blood sugar levels – and still do – long before the Cushings diagnosis and they are very normal. So…the quest continues. I’ll be having an IPSS (inferior petrosal sinus sampling) test perfomed soon. Nevertheless – here is the responses the Dr. Hershal Raff and Dr. Andre Lacroix, some of the leading experts in the field of Food-induced Cushings: RESPONSE FROM DR. Hershal Raff BLNDHRSE – "Food-induced Cushing’s" is commonly thought of as the expression of aberrant (usually not expressed) receptors on the adrenal gland. The most common form is the expression of receptors for GIP (glucose-dependent insulinotropic peptide). GIP is released in response to food and is involved in the stimulation of insulin during a meal. Food-induced Cushing’s is NOT consistent with elevations in ACTH since this is a form of "ACTH-independent Cushing’s syndrome." It is called ACTH-independent because the adrenal is the primary cause of the disease – autonomous or GIP-stimulated cortisol inhibits ACTH release via negative feedback. The post-prandial symptoms you describe are probably not caused by cortisol. However, it is possible that you have developed secondary diabetes due to cortisol-induced inhibition of insulin-stimulated glucose uptake. Have you ever had a post-meal blood glucose and insulin level done? That would definitely be worth doing – you may have early Type 2 Diabetes Mellitus secondary to cortisol excess. Food-induced Cushing’s is definitely not caused by a pituitary tumor and usually does not cause the acute symptoms that you describe. [Getting inferior petrosal sinus sampling (IPSS)] is EXACTLY what we would do (assuming that your urine free cortisol and bedtime salivary cortisols are elevated and that your plasma ACTH is not suppressed). Dr. Raff. Dr. Hershel Raff. Professor of Medicine and Physiology, Medical College of Wisconsin Director, Endocrine Research Laboratory St. Luke’s Medical Center Milwaukee, Wisconsin RESPONSE FROM DR. ANDRE LACROIX       BLNDHRSE – Dr Raff is right. GIP-dependent Cushing’s is an adrenal cause with suppressed ACTH. High cortisol levels often change appetite. In some patients with Cushing’s disease the normal stimulation of ACTH and cortisol which occurs after protein meals can be present in the pituitary ACTH-secreting tumor with elevations of cortisol and ACTH after meals. Dr. Lacroix Dr, Andre Lacroix, m.d. Chairman, Department of Medicine of CHUM Professor of Medicine Head, Laboratory of Endocrine Pathophysiology Research Center, H

Filed under: Pathophysiology

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